DNA Modification by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Rats
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چکیده
منابع مشابه
2-Amino-6-methyl-1,3-benzothiazole–decanedioic acid (2/1)
Co-crystallization of 2-amino-6-methyl-1,3--benzothia-zole with deca-nedioic acid under hydro-thermal conditions afforded the title 2:1 co-crystal, 2C(8)H(8)N(2)S·C(10)H(18)O(4). The deca-nedioic acid mol-ecule is located on an inversion centre. In the crystal, inter-molecular N-H⋯O and O-H⋯O hydrogen bonds connect the components into a two-dimensional wave-like layer structure extending parall...
متن کامل2-Amino-6-methyl-1,3-benzothiazole–octanedioic acid (2/1)
Cocrystallization of 2-amino-6-methy-1,3-benzothia-zole with octa-nedioic acid in a mixed methanol-water medium afforded the title 2:1 cocrystal, 2C(8)H(8)N(2)S·C(8)H(14)O(4). The octa-nedioic acid mol-ecule is located on an inversion centre. In the crystal, inter-molecular N-H⋯O and O-H⋯O hydrogen bonds connect the components into a three-dimensional network.
متن کامل2-Amino-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile
In the title compound, C(10)H(12)N(2)S, one of the C atoms of the cyclo-hexene ring (at position 6) and the methyl group attached to it are disordered over two sets of sites in a 0.650 (3):0.350 (3) ratio. The cyclo-hexene ring in both the major and minor occupancy conformers adopts a half-chair conformation. The thio-phene ring is essentially planar (r.m.s. deviation = 0.05 Å). In the crystal,...
متن کاملInhibition of choline synthesis in young rats by 2-amino-2-methyl-propanol-1.
2-Amino-2-methylpropanol-1 and LY ,a-dimethyltriethylcholine have been found to be competitive inhibitors of choline utilization in 40 to 50 gm. male albino rats (1). The former substance apparently only antagonized the utilization of choline in the kidney’ while the latter was an antimetabelite both in the liver and kidney. The quantitative relationships between these inhibitors and choline in...
متن کاملProstate mutations in rats induced by the suspected human carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Male lacl transgenic rats were fed a diet containing 200 ppm of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic amine present in cooked meats. PhIP was found to be a powerful prostate mutagen. After 61 days of treatment, the lacl mutant frequency was 71 x 10(-5), >20-fold higher than the spontaneous mutant frequency of 3.2 x 10(-5). The predominant PhIP-induced mutations ...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1989
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1989.tb01644.x